A role for hepatocyte growth factor/scatter factor in fetal mesenchyme- induced pancreatic beta-cell growth

Hepatocyte growth factor (HGF) acts as a mesenchyme-derived morphogenic factor during fetal lung development.

Mesenchymal-epithelial tissue interactions are important for development of various organs, and in many cases, soluble signaling molecules may be involved in this interaction. Hepatocyte growth factor (HGF) is a mesenchyme-derived factor which has mitogenic, motogenic and morphogenic activities on various types of epithelial cells and is considered to be a possible mediator of epithelial-mesenc...

Placental Insufficiency Decreases Pancreatic Vascularity and Disrupts Hepatocyte Growth Factor Signaling in the Pancreatic Islet Endothelial Cell in Fetal Sheep

Hepatocyte growth factor (HGF) and vascular endothelial growth factor A (VEGFA) are paracrine hormones that mediate communication between pancreatic islet endothelial cells (ECs) and β-cells. Our objective was to determine the impact of intrauterine growth restriction (IUGR) on pancreatic vascularity and paracrine signaling between the EC and β-cell. Vessel density was less in IUGR pancreata th...

A role for hepatocyte growth factor in diabetic retinopathy?

Hepatocyte Growth Factor: Its Role in Hepatic Growth and Pathobiology

GENERAL ASPECTS OF HEPATOCYTE GROWTH FACTOR STRUCTURE AND FUNCTION 612 Biochemical and Structural Properties of Hepatocyte Growth Factor Protein 612 Pathways of Activation of Hepatocyte Growth Factor 612 Structure–Function Analysis of the Hepatocyte Growth Factor Molecule 613 Hepatocyte Growth Factor Gene Organization 613 Hepatocyte Growth Factor Gene and Its Transcriptional Control 614 Hepatoc...

Hepatocyte growth factor mediates angiopoietin-induced smooth muscle cell recruitment.

Communication between endothelial cells (ECs) and mural cells is critical in vascular maturation. Genetic studies suggest that angiopoietin/Tie2 signaling may play a role in the recruitment of pericytes or smooth muscle cells (SMCs) during vascular maturation. However, the molecular mechanism is unclear. We used microarray technology to analyze genes regulated by angiopoietin-1 (Ang1), an agoni...